Hiv And Acquired Immunodeficiency Syndrome - 1557 Words

Many people do not understand what Human Immunodeficiency Virus (HIV) is and the difference been HIV and Acquired Immunodeficiency Syndrome (AIDS). As with other sexually transmitted diseases, HIV is often stigmatized due to the method of transmission. HIV is a virus that destroys CD4 T cells, which are immune cells in the body (Forsman Weiss, 2008). When the immune cells in the body fall to very low levels, this is when HIV progresses into AIDS. Since the immune system is weak a person can die from AIDS because of the inability to fight off infections, such as tuberculosis or pneumonia (Forsman Weiss, 2008). Approximately 1.7 million people in the United States have been infected with HIV, and more than 600,000 have died (AIDS.gov U.S. Department of Health Human Services, 2012). These numbers are very high, since the epidemic was only identified by the Centers for Disease Control and Prevention (CDC) in the 1980s (Krause, May, Butler Jr, 2013). The number of those infect ed with the disease are not accurate because researchers believe many people infected with HIV have not been diagnosed yet (Shahani, Hartman, Troisi, Kapadia, Giordano, 2012; Hallmark et al., 2014). Since it’s discovery there have been great improvements in the treatment of HIV and AIDS patients, although there is still no cure. There is an increased need for the diagnosis and treatment of the disease for men and women in the U.S. Those infected with HIV are not receiving the health careShow MoreRelatedHuman Immunodeficiency Virus ( Hiv ) And Acquired Immunodeficiency Syndrome1807 Words   |  8 PagesHuman Immunodeficiency Virus MGH Institute of Health Professions Joshua Igoe-Muzorewa â€Æ' Introduction Human Immunodeficiency Virus (HIV) and Acquired Immunodeficiency Syndrome (AIDS) continues to be an incredibly important health concern for not only the United States (US) but across the Globe (Centers for Disease Control and Prevention [CDC], 2016a). In the US alone, there are an estimated 1.2 million people that as of 2013 are living with the disease (CDC, 2016a). Scientists believe that HIVRead MoreAcquired Immunodeficiency Syndrome ( HIV ) : What Is The Cases Of HIV?1257 Words   |  6 PagesINTRODUCTION Acquired Immunodeficiency Syndrome (AIDS) caused by Human Immunodeficiency Virus (HIV) have always plagued the globe. According to the World Health Organization (WHO) Global Health Observatory (GHO), there are 36.9 million cases of HIV infections throughout the globe by the end of the year 2014 and 0.08% of adults with ages 15-49 years old are infected with HIV (World Health Organization, 2016). Also, according to the Joint United Nations Program on HIV/AIDS (UNAIDS), there was an averageRead MoreHuman Immunodeficiency Virus ( Hiv ) And Acquired Immunodeficiency Syndrome2589 Words   |  11 PagesOne of the most prevalent diseases facing the world today is human immunodeficiency virus (HIV) and acquired immunodeficiency syndrome (AIDS). HIV and AIDS became widely known on June 5th, 1981 when the US Center for Disease Control and Prevention (CDC) reported the first instance of this virus. Contrary to popular belief, being HIV positive is not a death sentence. Modern drugs make it pos sible for people who are HIV positive to be very healthy and live for years without developing AIDS. Also, thoseRead MoreThe Human Immunodeficiency Virus ( Hiv ) / Acquired Immune Deficiency Syndrome ( Aids )1199 Words   |  5 PagesThe Human Immunodeficiency Virus (HIV)/Acquired Immune Deficiency Syndrome (AIDS) is one of the deadliest pandemics the world has ever known. Unprecedented efforts and resources have been mobilized to fight the infection worldwide. While obvious progress has been made, HIV infection still hit hard and the field of public health continues actively to raise awareness about this issue and help affected people. Public health professionals constantly look for new ways to reach high-risk populations, butRead MoreHuman Immunodeficiency Virus ( Hiv ) And Acquired Immuno Deficiency Syndrome2096 Words   |  9 PagesHuman Immunodeficiency Virus (HIV) and Acquired Immuno Deficiency Syndrome (AIDS) are complex diseases that are generally misunderstood and cast a stereotype of the people who are infected. A disease that is relatively new in comparisons to some diseases came to light as a public issue in the 1980’s and is now known around the world. HIV and AIDS attack the T-cells and CD4 cells of a person’s body which make them have symptoms similar to the flu. This disease is exactly what the name describes Read MoreThe Human Immunodeficiency Virus ( Hiv ) Or Acquired Immune Deficiency Syndrome ( Aids )1281 Words   |  6 PagesA major epidemic across the world is the human immunodeficiency virus (HIV) or acquired immune deficiency syndrome (AIDS). Accredited with 10% of the HIV cases annually is injection drug use (AIDS.gov, 2014). A study done in 2010 showed that injection drug use affected nearly 47,500 new HIV infections in the United States. With 625 being males and 38% being female. Breaking it down even further, African Americans made up 50% of the newly affecting using injection drugs, Whites 26%, and Latinos/ Hispan icsRead MoreThe Human Immunodeficiency Virus ( Hiv ) And The Acquired Immune Deficiency Syndrome ( Aids )2072 Words   |  9 PagesIntroduction The Human Immunodeficiency Virus (HIV) and the Acquired Immune Deficiency Syndrome (AIDS) do not seem to be a major topic of discussion in the World today. Especially within the United States, HIV and AIDS are not conversed about as openly as perhaps it was in the past two decades. According to the Centers for Disease Control and Prevention (CDC) at the end of 2010 there were approximately 1.1 million people living in the United States with the HIV virus. Of those 1.1 million peopleRead MoreHuman Immunodeficiency Virus ( Hiv ) / Acquired Immune Deficiency Syndrome ( Aids )1449 Words   |  6 PagesHuman Immunodeficiency Virus (HIV) /Acquired immune deficiency syndrome (AIDS) is present around the world. HIV weakens the body’s immune system by attacking its defences against disease this later develops into AIDS which causes for the body to be unable to fight of illness and diseases it usually could (Afao.org.au, 2015). Chad a country of Sub Saharan Africa has an estimated 210,000 people living with HIV/Aids. Working to decrease this a number promotional incentives are being run such as theRead MoreHuman Immunodeficiency Virus Infection And Acquired Immune Deficiency Syndrome ( Hiv / Aids )898 Words   |  4 Pages Pathogenic Agent Identified Human immunodeficiency virus infection and acquired immune deficiency syndrome (HIV/AIDS) Virus after the infection of the human immunodeficiency virus (HIV), the immune system is damaged so the body become targets of many opportunistic diseases, which called syndrome, rather than just a type of disease. [1] History of Pathogenic Agent The clinical of AIDS was first observed by the US Centers for Disease Control and Prevention in 1981. [2] The region most recent outbreakRead MoreThe Human Immunodeficiency Virus, Or Hiv, The Root Cause Of Aids Or Acquired Immune Deficiency Syndrome?1532 Words   |  7 PagesSince its discovery in 1981, the scientific community has put up with the struggle of finding a vaccine for the human immunodeficiency virus, or HIV, the root cause of AIDS or acquired immune deficiency syndrome. Although numerous advancements in combating the virus have helped to reverse the epidemic, there is still no known cure. However, recent studies have shown some results that may possibly be the precursors to eradicate the disease. One example would be the trials of a possible vaccine conducted

Saturation Sampling Free Essays

The parameters that underpin quality research especially qualitative research keep changing and so the need for more clarity and transparency. The lucidity and transparency of reports from qualitative research form the basic philosophical foundation upon which the rigor as well as credibility of the qualitative study is evaluated. Qualitative studies are highly anchored on the quality of the reports generated and thus there is increased emphasis on the data collection stage. We will write a custom essay sample on Saturation Sampling or any similar topic only for you Order Now Given that all reliable targets may not be available to the qualitative researcher, the concept of saturation sampling allows the researcher to survey all the identifiable targets. In other words, saturation sampling helps researchers to overcome problems of lack of intentional sampling frames. For that reason, the researchers will attempt to survey all samples available. In addition, Fontanella et al (2008) add that saturation sampling allows the researcher to take a multifaceted approach in the study by removing the limits to the techniques of data collection, the mode of use, and the type of data collected. This boosts the reliability of the investigation by providing as much information as possible (Fontanella et al 2008). An example of a research study that employed data saturation is found in the ‘Public Understanding of Science- Journal’ titled ‘Ethno-cultural community leaders’ views and perceptions on biobanks and population specific genomic research: a qualitative research study’ by Godard et al (2010). The authors of the article note that due to the large gap existing due to lack of sufficient data on views and perceptions of communities on biobanks, their qualitative study required an in-depth interview of ethno-cultural leaders but the public’s involvement was also important. In the conclusion of the study, the researchers found that leadership and general public must equally be involved in the partnership even if the public is not informed of the significance of the biobanks. In addition, the model allowed the researchers to identify various socio-cultural and ethical issues that impact on the effective performance of biobanks. How to cite Saturation Sampling, Papers

Virtualization Technology

Question: Discuss about the Virtualization Technology. Answer: Introduction Virtualization is the creation of simulated versions of IT elements such as Operating Systems, storage devices, servers or network resources (Portnoy, 2016). Kumar Charu (2015) define virtualization as an arrangement of software and hardware configurations that constructs Virtual Machines (VMs) and facilitates the execution of more than one operating systems running on the same physical resources and platform. In addition, virtualization can be referred to the resourceful utilization of the present resources that offers gigantic cost savings in a short amount of time. Virtualization also delivers organizations with fresh models of software deployment which meets user anticipations, offers quick services, self-service provisioning, scalability and load balancing to support important business systems. The illustration below shows a virtual IT infrastructure (Kumar Charu, 2015). Figure 2: A Virtual Infrastructure (Source: Metzler, 2011) Role of virtualization in a data center According to VMware White Paper (2016), virtualization enables enterprises to handle challenges that include the following Server consolidation - virtualization removes the need for many servers in an organization that are not used to their full capacity by using only one server and deploying other required servers as virtual machines (VMs) which can therefore execute safely across shared resources plainly which thus increases server usage and utilization to optimized levels. Since many servers including mail servers, webservers, and network servers usually use less than forty percent of their capability, deploying them as virtual machines in only one server saves physical space, consumes less power and reduces on organizational costs. Development and test environment standardization and optimization virtualization enables the provision of development and testing servers by recycling configured systems, augmenting collaboration between system developers and allows standardizing development environments which increase system compatibility, thereby reducing developer conflicts and errors. Organizational sustainability and continuity - virtualization reduces the expenses and complications of business sustainability by providing the availability of disaster recovery solutions by compressing major systems into single system files that can be simulated and reinstated on other server thereby decreasing downtime and system resources. Enables secure enterprise desktop virtualization provides user workstations, personal computers and laptops with secure platforms without conceding their autonomy by offering security policies in applications surrounding virtual desktop machines. Need and importance of virtualization technologies Virtualization is a major factor to business organizations since it is an enabling technology that allows the creation of an intelligent abstraction layer that hides the difficulty of underlying software or hardware (Kumar Charu, 2015). Virtualization technologies allows business enterprises to reduce costs on both hardware and software purchases and split computing resources to gives one or more than execution environments (Naeem et al, 2016). Virtualization is a major part of contemporary design for data center (Onisick, 2010). Virtualization technologies are necessary and organizational should implement them because of the following benefits as laid out by Naeem et al (2016). Reduction in infrastructure costs including cooling, power, spacing and cabling, due to less required server hardware which consequently saves money. Centralized management and monitoring tools exist for most virtualization platforms which maximizes uptime Improved hardware utilization since traditional servers only use up to 10% resources.Placing multiple virtual machines on the same physical server achieves high utilization. Availability, reduction in system administration work and management benefits Virtualization in Amazon Founded in 1994, Amazon is an Americancloud computing and electronic commerce company. It is the leading web based retailer in the world by total sales and market capitalization having started as an online bookstore (Amazon, 2017). To satisfy it large base of clients and customers, Amazon has implanted virtualization technologies. Amazon Virtual Private Cloud VPC allows for the provision of a rationally secluded segment of their Web Services cloud where a client can introduce web resources in a self-defined virtual network. The customer has complete control and management over the virtual networking setup, comprising of their specific address ranges, gateways, subnet creation, and route table configuration (Amazon, 2017). Major attributes of a VM A virtual machine (VM) is the basic component of virtualization and act as a container for operating systems and application software executing on top of the virtualization layer on a server (Portnoy, 2016). VMs offer several benefits for IT infrastructure in a business organization. Major attributes of an efficient virtual machine (VM) include the following Hardware Independence - VMs should have the capability of migrating to any physical server Partitioning- ability to run more than one operating systems on one physical machine and provision to divide system resources among virtual machine Safety and Isolation at the hardware level, VMs should provide security and fault isolation. In addition, with progressive control of the system resources, they should be able to preserve machine performance. Encapsulation virtual machine files should be saved and hidden from access and contact by other systems. The files also should have the capability of moving from one location to another. Fidelity The environment it creates for the VM is essentially identical to the original (hardware) physical machine. Performance - between the physical equivalent and the VM there should be little or no difference at all. Points to consider when using VM as a server Workload capacity and performance planning server virtualization greatly increases resource utilization, to ensure efficient running of a VM server, workloads , capacity and performance should be kept in check. Security - security is a very key factor in computer systems. To ensure that servers are working effectively, security has to be set in place to inhibit any possible threats. Operational processes and procedures ensure that procedures and policies on how to run, monitor and control the VM server are in place. Storage apportionment and management storage allocation should be estimated so that currently available capacity is not exceeded which can subsequently affect server performance. Virtual appliance vs vApp A virtual appliance is a preconfigured application software that contains virtual machines(VMs) and software solutions that are combined, integrated, controlled and reorganized as a unit (VMware Inc, 2010). Avirtual applianceis usually setup ready to run on ahypervisor. Virtual appliance is created when a software appliance is installed on a virtual machine and packaged into an image. Virtual appliances are usually anticipated to exclude the setting up, configuration and upkeep costs linked with the execution of complicated heaps of software applications (Bhartiya, 2015). A virtual appliance is easy for users to obtain and implement as solutions. Virtual appliances make the development and the dissemination of software applications simpler and reduce the execution time. vApp A vApp contains several interoperating virtual machines (VMs) and software applications that can be installed and managed as one element. vApps use standard Open Virtualization Format to compress elements of a given application, alongside operating procedures and service levels agreements associated with them. A vApp gives software developers a typical way of describing procedures and policies that the clouds or datacenters they are using can be consistently interpreted and executed (VMware Inc, 2010). A vApp offers a suitable method of using software applications without the complication of installing the applications yourself (SAS, 2016). When to use a virtual appliance When you want to isolate the host operating system especially when testing software applications When you want to save on hardware and software costs of a business organization When a company does not have enough physical space for setting up all the required hardware and software equipments When a company want to implement centralized management of all its resources and communication Virtual appliance suppliers :VMware Inc. VMware delivers virtualization and cloud applications and services (VMware Inc., 2010). VMware leads in both server and desktop virtualization markets. VMware continues to lead the virtualization market due to inventions, tactical connections and quality products (Hess, 2016). Desktop software at VMware operates on Linux, macOS AND Microsoft Windows. Sever Hypervisors run on VMware ESXi and VMware ESX. The two are bare-metalhypervisorsoperating openly onserverhardware without the necessity of needing an extraoperating system (OS). Citrix Systems Inc. Citrix Systems, Inc.is an American corporation founded by Richardson in the late nineties. Citrix provides desktop, server and application virtualization, cloud computing services and software as a service(SaaS). Citrix started by creating remote access applications including remote servers. The company has other development centers in countries including Canada, Australia, United Kingdom, Denmark, India and Germany (Citrix, 2017). Microsoft Microsoft has been a leading software provider for many years now. To compete in the server virtualization market, Microsoft developed a non-Linux hypervisor and continues to offer striking authorization for the hypervisor product together with the operating systems running on it (Microsoft, 2017).The hypervisor continue getting more and more competitive for virtualization after every new release of a new Windows server. The company has also continued to gain clients for their virtualization services including Hyper-V services. References Amazon (2017). Amazon Com Inc. Retrieved from https://www.amazon.com/ Bhartiya, S. (2015). Why, When, and How To Use a Virtual Machine. Retrieved from https://www.linux.com/learn/why-when-and-how-use-virtual-machine Citrix (2017). What does Citrix do? Retrieved from https://www.citrix.com/about/what-does-citrix-do.html Hess, K (2016). Top 10 Virtualization Technology Companies for 2016. Retrieved from https://www.serverwatch.com/server-trends/slideshows/top-10-virtualization-technology-companies-for-2016.html Metzler, D. (2011). Virtualization: Benefits, Challenges, and Solutions, White Paper. Retrieved fromhttps://www.stotthoare.com.au/sites/default/files/files/1_16100_WhitePaper_VirtualizationBenefits_by_Webtorials.pdf Microsoft (2017). Microsoft Hypervisor. Retrieved from https://www.microsoft.com/en-us/cloud-platform/server-virtualization Naeem, M., Mahar, H., Memon, F. Rauf, A. (2016). An overview of virtualization cloud computing. Retrieved from https://www.researchgate.net/publication/307905618_AN_OVERVIEW_OF_VIRTUALIZATION_CLOUD_COMPUTING Portnoy, M. (2016). Virtualization Essentials. Second Edition. ISBN: 978-1-119-26772-0 Kumar, R., Charu, S. (2015). An Importance of Using Virtualization Technology in Cloud Computing. Global Journal of Computers Technology, Vol. 1, No. 2, February 25, 2015, ISSN: 2394-501X. Retrieved from https://www.researchgate.net/profile/Rakesh_Kumar175/publication/273723426_An_Importance_of_Using_Virtualization_Technology_in_Cloud_Computing/links/5509bd980cf20f127f907ce3.pdf Onisick, J. (2010). Data center 10: server virtualization. Retrieved from https://www.definethecloud.net/tag/data-center-virtualization/ SAS. (2016). What is a vApp and how does it work? Retrieved from https://support.sas.com/software/products/university-edition/faq/vmapp_whatis.htm VMware Inc (2010). Users Guide to Deploying vApps and Virtual Appliances. Retrieved from https://www.vmware.com/support/developer/studio/studio21/va_user.pdf

Japan and Imperialism 1853

Introduction James Huffman is the author of the book, Japan and Imperialism 1853-1945. The author uses a dazzling and interactive sequence of events to tell how Japan dealt with the challenge of foreign policy and victimization from colonizers. The author engages the reader by explaining how Japan responded to these challenges.Advertising We will write a custom book review sample on Japan and Imperialism 1853-1945 by James Huffman specifically for you for only $16.05 $11/page Learn More Adoption and promotion of imperialism in Japan had numerous effects on the country’s development strategies, as well as the welfare of citizens (Huffman 10). In addition, the author analyses the country’s imperialism framework in terms of its positives and negatives. The book examines many issues about development in Japan, as well as various empirical and theoretical concepts on the same. This essay provides a detailed review of the book by identifying and analyzing various concepts and topical approaches. Problem: Questions/Issues Examined by the Author The issue addressed by the author in this book is how Japan managed to establish itself as an economic and political powerhouse in Asia. James Huffman applies his literacy prowess to provide a detailed and sequential recitation of how Japan redeemed the sovereignty of its people amidst the pressures of imperialism and colonization from western nations (Huffman 15). In addition, the author identifies the problem of pressure coming from Japan’s domestic settlements and administrative districts, which made it hard to achieve effective management of resources. The challenge of imperialism and colonialism was hard for Japan to deal with, as it was targeted and victimized for practicing a learned profession (Huffman 19). Significance of the Book in Understanding Asian Studies The book is very useful and significant because it helps the reader gain better understanding of historical f acts about Japan. The author incorporates pictures, an alphabetical list of technical terms used in the text, chronology of events, endnotes, and references for anyone interested in expounding their knowledge on any concept developed in the reading. The author has extensively covered all the important happenings for the entire period from 1853 to1945. It is during this period when the world first experienced Japan. It is also the time the Asian country gave in to the demands of the colonial masters following the bombing of its two major cities (Huffman 26). The two cities bombed by the western colonial masters were Nagasaki and Hiroshima.Advertising Looking for book review on asian? Let's see if we can help you! Get your first paper with 15% OFF Learn More Following the bombings, Japan allowed the western colonial masters to extend their rule over its people. The author gives an in-depth analysis of how imperialism shaped Japan in terms of economic development, technol ogical growth and adaptation, as well as improvement of its political system (Huffman 29). The reading provides detailed, reliable, and informative facts about Japan’s history during the period covered. I would recommend this reading to anyone interested in learning how Japan has managed to remain resilient in its efforts to become a global powerhouse. The period covered by this reading has all the right information on what shaped Japan’s economic and political agendas. Theoretical and Topical Approach of the Author in the book The theoretical approach applied by the author is one that explains the concept of imperialism and how it helped to shape Japan’s development strategies. The main topic in the reading is imperialism, which the author believes motivated Japan to economic and political development. Because of foreign policy influence, Japan was able to develop effective policies for economic development, as well as create an inclusive political system that focused on improving the welfare of all citizens (Huffman 41). In addition, the author explains how the concept of imperialism helped Japan to amplify its borders. Expansion of administrative borders helped Japan to enhance its resource capacity that was influential in development of better technologies. In the reading, the author gives an example of the city of Hokkaido, where residents benefited from technical institutions set up to develop their farming practices through better technologies (Huffman 45). Other cities benefited from hosting military camps for colonial missions in other regions and countries across the Asian continent. Imperialism helped to empower the people of Japan economically, through their various projects and missions. The author uses an interactive approach to explain the concept of imperialism, and how it helped Japan to develop an inclusive political system. The influence of foreign policy made Japan open up to the idea of developing relations with other countries.Advertising We will write a custom book review sample on Japan and Imperialism 1853-1945 by James Huffman specifically for you for only $16.05 $11/page Learn More This resulted in the signing development agreements with other countries that also built embassies in the country (Huffman 49). According to the author, these developments played a crucial role in Japan’s expedition to economic independence and better international trade relations. Key Concepts: Main Empirical and Theoretical Concepts The author presents four important concepts throughout the reading. The four concepts are victimization, foreign policy, patriotism, and contemporary foreign policy. The author defines colonialism as the strategy of victimizing people from outside one’s self-governing boarders through possession and control (Huffman 63). The other concept presented by the author is foreign policy, which refers to instances where a country aggressively ext ends its authority over other people by imposing its policies on them (Huffman 66). The author uses Japan, a victim of foreign policy to expound on this concept. Patriotism is another concept present in the reading. The author defines patriotism as the commitment that people show towards their nation by supporting its various interest areas and cultural practices that define its identity. However, the author warns that patriotism can take either a positive course or a negative course, depending on policy frameworks used by a government (Huffman 68). The final concept presented in the reading is contemporary foreign policy. The author explains this concept as a strategy that is applied by influential western nations to acquire more colonies in Africa and Asia. Summary of Argument to the Reading Japan and Imperialism 1853-1945 is a book that presents many interesting, informative, and knowledgeable realities about Japan (Huffman 2). The book has few pages, which means that the author has not extensively covered the history of Japan. The author addresses various elements of Japan’s history, albeit in very diminutive detail. The main arguments presented in the reading by the author focus on imperialism, colonization, opening up of Japan to the rest of the world, impacts of foreign policy and victimization on Japan’s development agenda (Huffman 53). Other arguments developed in the reading talk about how Japan dealt with World War II and the economic depression.Advertising Looking for book review on asian? Let's see if we can help you! Get your first paper with 15% OFF Learn More Data and Evidence Presented The author applies a variety of data to present the concept of imperialism in Japan’s history. The data comprises narratives about influential individuals from western colonies, who contributed towards guiding Japan’s development agenda (Huffman 17). The references used are quite reliable, as they come from credited sources such as novels and journals. The author also uses data from articles printed following research studies by Ivy League institutions, such as Stanford University and the University of Washington (Huffman 79). The use of reliable data has made the book a worthy read and a legitimate reference for future studies. Validity of Accounts and Arguments in the Reading The author uses a very persuasive style of writing, which validates the arguments developed in the reading. Although the narrative is not long enough, the author has managed to provide accurate data that convinces the reader. The use of reliable and easily accessible sources further validates information provided in the reading. This provides an opportunity for a reader to do further reading on various concepts and theories applied in the reading (Huffman 79). I can confidently say that the book is valid and convincing enough for any reader who wants a reliable source on Japan’s history. Strengths and Limitations of the Reading Imperialism and Japan 1853-1945, is an amazing book that provides an interesting summary of Japan’s rich history in few pages. The four concepts developed in the reading are sufficient in providing the reader with necessary information on the subject (Huffman 10). Clear elaboration of concepts and theories in the book makes it easy and interesting for the reader to have deep understanding of its content. Use of chronology, endnotes, and a detailed timeline makes the reading to stand out and appealing to a reader. I would highly recommend this book to anybody interested in learning Japan’s rich history . Works Cited Huffman, James. Japan and Imperialism: 1853-1945. New York: Association for Asian Studies, 2010. Print. This book review on Japan and Imperialism 1853-1945 by James Huffman was written and submitted by user Carlos Munoz to help you with your own studies. You are free to use it for research and reference purposes in order to write your own paper; however, you must cite it accordingly. You can donate your paper here.

Everyday French Phrases

Everyday French Phrases There are some French phrases that you will hear literally every day or even multiple times a day and even use yourself. If you are studying French, or plan to visit France, its important that you learn and practice five often-used French phrases. Ah Bon Ah Bon  literally means oh good, though  it  commonly translates into English as: Oh yes?Really?Is that so?I see. Ah bon  is used primarily as a soft interjection, even when its a question  where a  speaker is indicating interest and maybe a little surprise. The examples list the French sentence on the left with the English translation on the right.      Speaker 1:  Jai vu un film intà ©ressant hier.  I saw an interesting movie yesterday.  Ã‚   Speaker 2: Ah  bon?     Oh, yes? Or in this example: Speaker 1: Je pars aux États-Unis la semaine prochaine.   Im going to the United States next week.  Speaker 2: Ah bon? Really? Ça va Ça  va  literally means it goes. Used in casual conversation,  it can be both a question and a reply, but its an informal expression. You probably wouldnt want to ask your boss or a stranger this question unless the setting was casual. One of the most common uses of  Ãƒ §a  va  is  as a greeting  or to ask how someone is doing, as in: Salut, Guy, à §a va?   Hi, Guy, hows it going?Comment à §a va?   Hows it going? The expression  can also be an exclamation: Oh! Ça va!   Hey, thats enough! Cestdire Use cestdire when you want to say I mean or that is. Its a way to clarify what youre trying to explain, as in: Il faut à ©crire ton nom l, cestdire, ici.   You need to write your name there, I mean, here. Il faut que tu commences y mettre du tien ici.   You need to start pulling your weight around here. Il Faut In French, its often necessary to say its necessary. For that purpose, use il faut, which is the conjugated form of  falloir,  an  irregular French verb.  Falloir  means to be necessary or to need. It is  impersonal, meaning that it has only one grammatical person: the third person singular. It may be followed by the subjunctive, an infinitive, or a noun. You can use  il faut  as follows:   Ã‚  Il faut partir.  Ã‚  Its necessary to leave.  Ã‚  Ã‚  Il faut que nous partions.   We have to leave.  Ã‚  Ã‚  Il faut de largent pour faire à §a.   You need money to do that. Note that this last example literally translates to, Its necessary to have money. But, the sentence translates into normal English as You need money to do that, or You have to have money for that. Il Y A Whenever youd say there is or there are in English, you would use  il y a in French.  It is most commonly followed by an  indefinite article   noun, a  number   noun, or an  indefinite pronoun, as in: Il y a des enfants l-bas.   There are some kids over there.Jai vu le film il y a trois semaines.   I saw the movie three weeks ago.Il y a 2 ans que nous sommes partis.   We left two years ago.

How to Form and Use Possessive Adjectives

How to Form and Use Possessive Adjectives Possessive adjectives are used to show ownership of an item or an idea. Possessive adjectives are very similar to possessive pronouns and the two are often confused. Take a look at these examples of possessive adjectives immediately followed by possessive pronouns used in a similar sense. Possessive Adjective Examples My dog is very friendly.Her book is red.Our house is painted yellow. Possessive Pronouns Examples That friendly dog is mine.The red book is hers.That yellow house is ours. If you are unsure focus on the placement of possessive adjectives which are placed directly before the noun they modify. Possessive Adjectives Usage Possessive adjectives are used when the reference to which person or thing is understood. For example: Jack lives on this street. His house is over there. The possessive adjective his refers to Jack because of the context. Remember that possessive adjectives come in front of the noun they modify. Here is a list of possessive adjectives: I - my carYou - your dogHe - his boatShe - her familyIt - its fabric(NOT its!)We - our classYou - your jobsThey - their toys Examples: I took my daughter to the movies.Where is your house?I picked up his book yesterday.Thats her car over there.Its color is red!Our company is doing very well.Your bicycles are located in the basement.Their toys are in the closet. Possessive Adjective Checklist Possessive adjectives are used in place of proper names Place adjectives directly before the noun they modifyPossessive adjectives are very similar in usage to possessive pronouns Possessive adjectives are used when the context is clear who is in possession of an objectNote the similarity in form between possessive adjectives and pronouns Use these resources for more detailed information on other possessive forms: Possessive Nouns - For example, Johns house, the bicycles color, etc. Possessive Pronouns - For example, that is mine, this is hers, etc. This general guide to possessive forms quickly compares all three types of possessive forms.

Paper on Arabidopsis cold responses Essay Example | Topics and Well Written Essays - 1000 words

Paper on Arabidopsis cold responses - Essay Example It is widely speculated that the products of these genes have roles in freezing tolerance. The aim of this experiment was to provide direct evidence that supports this hypothesis. It shows that expression of COR15a, which is a cold-regulated gene of Arabidopsis thaliana that encodes a chloroplast-targeted polypeptide, enhances the freezing tolerance of chloroplasts in nonacclimated plants. The Effects of Cold Stress on the Cor15a Promoter of Arabidopsis thaliana In 1985, Guy et al. established that transformations in gene expression occurred in plants during cold acclimation, which is a developmental mechanism that leads to increase in freezing tolerance. Since then, it has continuously been speculated that some COR (cold-regulated) genes might play roles in freezing tolerance. To investigate this notion, scientists have isolated and characterized genes expressed as a response to low temperature. This has led to the identification of a number of genes such as the cor15a, KIN1, and LT I78 genes of Arabidopsis thaliana; and the pt59 and pao86 genes of barley (â€Å"Genome research†, 1995). Arabidopsis thaliana is widely used in botany as the model organism for studying plant genetics and growth responses. This plant is a member of the mustard (Brassicaceae) family, which includes cultivated species such as cabbage and radish. Although Arabidopsis thaliana does not have any major agronomic importance, it has advantages that make it ideal for use in research in the fields of genetics and molecular biology. The first advantage of Arabidopsis thaliana that make it favorable for research  is its small physical size, its fast growth rate, its capability in seed production, its genetic amenability to mutagenesis and transgenic approaches, and the widely available information on its genome. Secondly, Arabidopsis thaliana is well-suited for analysis with light microscopy. Its seedlings and their roots are translucent and smaller, thus they facilitate live cell ima ging with fluorescence and confocal laser scanning microscopy. Lastly, Arabidopsis thaliana is the first plant genome to ever be sequenced. This was completed in 2000 by the Arabidopsis Genome Initiative (Stewart, 2008). Most plants react to low temperatures by altering their intracellular concentrations of free amino acids and carbohydrates, isozyme patterns, and the composition of their membranes. Moreover, in response to low temperatures, there is an alteration in the activity of many genes. Dr. Michael Thomashow of Michigan State University conducted studies on how plants respond to cold temperatures. He examined cold-induced genes in the plant Arabidopsis and cloned cor (cold related) genes. One of these genes, cor15a, is induced by cold temperatures, drought, and the hormone abscisic acid. Cor15a is a nuclear gene that encodes a 15 kDa protein. The function of this protein is unknown. This 15 kDa protein is translated to chloroplasts and it may have a function in plant protect ion from cold. (Baker et al., 1994) isolated a DNA fragment that contained a promoter region and a few amino acids from the cor15a gene. They then joined it to the gusA gene, thereby producing a cor15a-gusAtranslational fusion which was introduced into Arabidopsis thaliana using Agrobacterium. This reporter gene is used in monitoring the response of the cor15agene in varied plant tissues. In this laboratory investigation, transgenic

The Advocacy for the Use of Nuclear Energy as a Sustainable Source but Essay

The Advocacy for the Use of Nuclear Energy as a Sustainable Source but a Control of Its Proliferation - Essay Example An increase in it use will foresee a replacement of the green house gases that bring about global warming and able to foster development. The increase will by far bring about a ‘sustainable development’, which was a term coined by the Brundtland commission whose intention were to protect the future generations while minimizing depletion of the same resources at present. This paper therefore offers insight on the issue of increasing nuclear energy so as to meet the global energy needs that the (world energy) council contends as being huge to meet the efficiency within which energy is provided. However, the paper is still cautious of the negativity involved with the issue such as the proliferation and the threats it brings about. Reviews The proposal exposes the intricate relationship that exists between the use of the energy and the impact it has on the environment. The proposal is about the increase of the use of the nuclear energy to supplement the existing sources of e nergy. The advocacy for the increase in the usage of nuclear energy does not imply ignorance should be made in regards to the threats that exist. This underlies the fact that there has to exist laws and regulation that govern the usage and production of such. This ensures caution and a further responsibility to be held by countries that get involved. The proposal offers the alternative to the prevention of what is being envisioned; which is global warming and a world that will have sustainable development through the production of nuclear energy. The proposal hence offers both an analytical and critical outlook of where the world is ending in terms of the sources of energy and the path within which it is to be undertaken to make these world a more efficient and safer place. Hypothesis The belief is that the current sources of energy that include fossil fuels (such as coal and oil) are becoming exhausted at an alarming rate, such that within the next decade they may be depleted. This leaves the question of how humans will sustain themselves and hence the need for an alternative source of energy that should be dependable and exist in limitless nature. Nuclear energy is believed to be resourceful in that it can provide what is required to supplement or become the existing source of energy. Long Term Objectives The objectives that are likely to become the long term are one that will make nuclear energy a sustainable energy source that will be reliable and have no harm to the environment. The perceived lack of emissions of green house gases is revelation that it holds the future for sustainable energies. The world will be able to achieve energy in ways that are environment friendly and are not a threat to its existence. The advancement of continued use of fossil fuels has been seen as one that erodes the environment whereas the research in fusion energy provides more attractive commercial products. To this end, studies have confirmed that the cause of global warmin g is mainly the release of green house gases. This then means that nuclear energy is not among the factors that lead to global warming, an indication that it is a clean energy for the present and future. Background It is without a doubt that the world stands threatened due to the global warming. This is so because since 1950, the world’s climate has been warming, primarily as a result of emissions from fossils. The term global warming has therefore become a

The wider events of he Crucible Essay Example for Free

The wider events of he Crucible Essay Furthermore, Johns power within the town (and his rebellious attitude) could be likened to that of extra salt in a pot, spicing up the broth; moreover, this line foreshadows Johns impact on the trials later on in the play: his confession to lechery, admittance that he saw the boots of Lucifer and accusation that the court is pulling Heaven down and raising up a whore These actions undermined the authority of the court and so greatly influence Salem; the theme of trial is also prevalent in The Crucible and the actions John Proctor takes in standing up to the court loosely reflect Arthur Millers denouncement of the House of Representatives Committee on Un-American Activities . In reference to the title of the play, John Proctor putting more salt into the stew is analogous to his actions stirring up the situation in Salem, which can be likened to that of a crucible- a melting pot used to remove impurities from precious metals. Additionally, Johns relationship with Elizabeth is symbolic of the towns puritan culture; it is very mundane and based upon stringent Christian morals. The act of John adding salt to a brand broth indicates his need for a more exciting and zestful relationship- which John finds in Abigail Williams. Elizabeth Proctor is the victim of the sins perpetrated by John and Abigail, and though she is a pious and devout Christian wife she is not wholly innocent and is partially to blame for the deterioration of her marriage. One of the themes throughout John and Elizabeths marriage is that Elizabeth is very cold towards John and that it is this sternness which drives John to Abigail; Miller uses the pragmatics of words to convey this feeling, with phrases such as You ought to bring some flowers into the house and It is winter in here yet Miller demonstrates that John feels that Elizabeth has been cold to him and wants to tell her this- yet cannot, because he doesnt want to anger her (I mean to please you, Elizabeth); he also uses this dialogue to indicate the general atmosphere of Salem as a whole, full of deceit and small talk to mask over the insecurities and sins beneath. John desperately craves forgiveness from Elizabeth and she must absolve him, (because divorce was unthinkable in a deeply religious town such as Salem) but she finds it hard to forgive him because he has committed Adultery, one of the ten commandments and therefore highly important to a devout Christian, and because he has further de nted her self-esteem I counted myself so plain, so poorly made, no honest love could come to me! by sleeping with another woman. John, however, is not the cause of Elizabeths low self-worth- the repressive nature of Salem is. In Salem, women arent allowed to express themselves, which leads to two extremes: one extreme is the kind of wild exhibitionism expressed by Abigail, Tituba (and various others) at the beginning of the play; or the other extreme of self-repression and not letting your true feelings be known, like Elizabeth. Without the ability to experience the things teenagers go through during pubity, Elizabeth is led to believe that no man finds her attractive and doesnt know how to trust them. Ergo, when John has an affair Elizabeth doesnt know how to forgive him and so Miller uses language to make their relationship seem like a trial, with phrases such as Oh, Elizabeth, your justice would freeze beer! (Use of imagery) The magistrate sits in your heart that judges you (Use of metaphor) and You will not judge me more, Elizabeth. In Act 2, when the accusations are just beginning, and have not affected the Proctors, John and Elizabeth feel no passion in their marriage and are struggling to make it work- but as the hysteria escalates, the adversity draws them closer together and rekindles their love. This rejuvenation is foreshadowed by talk of spring in Act 2, and also hints at Elizabeths pregnancy, well see green fields soon. Massachusetts is a beauty in the spring; the reason Miller includes these phrases in the dialogue between John and Elizabeth is to show that John wants a fresh start and is also literally looking forward to the spring time, as well as to provide clues for the audience as to what will happen later in the play. In Act 3, both John and Elizabeth show great courage and both do it to try and do what is best for each other- John confesses to lechery in a bid to discredit Abigails accusations and save his wifes life, even though doing do will ruin his good name and lead to a bad reputation in Salem; Elizabeth lies about Johns infidelity in an act of loyalty to her husband because she wants to protect his good name, even though she is a pious woman and by lying she is committing a grave sin, God damns all liars this shows Elizabeth values her husband more than her God. This scene is ironic because though both John and Elizabeth show great courage and loyalty, they damn themselves because John says that Elizabeth never lied and cannot lie, but she goes on to lie in an act of loyalty- even though telling the truth would have saved him from hanging. Reverend Hale sees that it is a natural lie to tell and that Elizabeth was just showing loyalty to her husband, but Danforth is too bigoted to see this, and is only interested in finding people guilty of witchcraft so he can exert his power. Miller clearly based Danforths character on Senator Joseph McCarthy to show that he sees McCarthy as a bigoted, power-hungry tyrant who is only interested in looking powerful and eliminating people who threaten his position. By Act 4, John and Elizabeth have become united through their ordeal and this is signified in their language, which is far more emotive, John says You are a marvel- Elizabeth, which shows that John is again madly in love with Elizabeth and wants to express how much he cares for her. The progression of their relationship is echoed by the development in the wider events of the story: Reverend Hale has denounced the court and is trying to save [Johns] life because damnations doubled n a minister who counsels men to lie; the people of Salem have started to rebel against the court you wander yet if rebellions spoke? Better you should marvel how they do not burn your province! and they have put a dagger in Parris door. It seems like Salem is being purified, much like gold in a crucible, and all the deceit and pretence is being washed away. Additionally, as the witch trials come to their conclusion, the trial within the Proctors marriage also comes to its resolution and this is the salvation John Proctor is searching for. Miller demonstrates this purification in Johns mind using stage directions, Elizabeth says I cannot judge you, John, there is a pause, and John says What would you have me do with the stage direction simply, a pure question; the word pure here indicates that John feels like he is close to redemption and this is confirmed when he says I would have your forgiveness, Elizabeth. Miller chose to make he dialogue which follows strikingly emotionally charged, because it is when John is finally given forgiveness, there are emotive stage directions such as he stands, as though with physical pain she is on the verge of tears and now pouring out her heart. There are many references back to the earlier themes in the play, of coldness and of trials; Elizabeth admits her faults suspicion kissed you when I did it were a cold house I kept!, gives John the forgiveness he craves, whilst referencing the idea of their relationship as a trial But let none be your judge I cannot judge you John, I cannot! I am not your judge, I cannot be (as though giving him release. ) and even asks for Johns forgiveness herself, forgive me, forgive me, John- I never knew such goodness in the world. The contrast in speech between act 2 and act 4 is staggering, whereas in act 2 John and Elizabeth exchanged pleasantries which cloaked their real feelings of uneasiness between each other, in act 4 they pour their hearts out and shower one another with compliments- it is a very beautiful passage made all the more precious by John Proctors impending death. Galvanised by his redemption and love for Elizabeth, John realises that the only way for him to truly forgive himself and appease the magistrate that resides within his own heart is to accept his hanging and make sure his name is not blighted by the cowardice of a false confession, How may I live without my name? I have given you my soul; leave me my name I do think I see some shred of goodness in John Proctor. Not enough to weave a banner with, but white enough to keep it from such dogs. The bravery John shows here is only possible because of the purification of his marriage and that his death would help cleanse the deceit and repression of Salem. The Proctors final act as man and wife is to share a kiss with great passion, exactly what was missing in their marriage after Johns affair with Abigail. Elizabeth speaks the final line of The Crucible and gives the audience closure on the literal witch trials of Salem, and her own personal trial within her marriage, and gives both herself and John the resolution they both desperately sought, He have his goodness now. God forbid I take it from him. In conclusion, The Crucible is an exceptionally nuanced play with myriad deep-rooted themes which can only be truly appreciated by absorbing every subtle word which Miller provides us with, and engaging with the pragmatics conveyed by either the actors reciting the play, or conjured by your own brain whilst reading. The Crucible works very well as an allegory for McCarthyism in America, beautifully juxtaposes the Seven Deadly Sins against the Ten Commandments and develops the story in parallel with the relationship of John and Elizabeth Proctor, whilst evoking a real sense of the social, historical and cultural climate of 17th Century Massachusetts. Above all, The Crucible is a fascinating and emotional play which was a pleasure to read and analyse. Kyle Sawhney Show preview only The above preview is unformatted text This student written piece of work is one of many that can be found in our GCSE Arthur Miller section.

Essay --

Wernekink commissure syndrome secondary to ischemic stroke: severe dysarthria is one of the main characteristics of this syndrome Introduction Pure midbrain infarctions are relatively rare. Several midbrain syndromes such as Weber’s, Claude’s and Benedikt’s syndrome had been described extensively before. Because of its rarity, clinicians do not frequently confront Wernekink commissure syndrome, but it is one of the midbrain syndromes. Wernekink commissure involves the decussation of dentatorubrothalamic pathway, which provides cerebrocerebellum connections through superior cerebellar peduncle in midbrain. Its main characteristics are bilateral cerebellar dysfunction, occasional oculomotor signs including internuclear ophtalmoplegia or palatal tremor [1-3]. We report a case of a patient with Wernekink commissure syndrome due to focal infarction in the caudal paramedian midbrain presenting with anarthria and bilateral cerebellar ataxia. Case Report A 62-year-old male current smoker was admitted to stroke unit in our hospital because of sudden onset dizziness, impaired speech and gait disturbance. He could barely walk without assistance. On admission day, his vital signs were normal except a blood pressure of 162/94 mmHg. He was alert and not dysphasic but his pronunciation was markedly slurred. He could not pronounce a single syllable. The extraocular movements were full, but he showed saccadic pursuit in all directions. Upbeating nystagmus appeared when he gazed upward. All limb extremities showed Medical Research Council (MRC) Grade 5 motor power and sensory examinations did not reveal any abnormality. Motor incoordinations were detected with finger-to-nose, heel-to-shin and rapid alternating movement test on both sides, the le... ...in the adult]. Revue neurologique 98 (6):435-477 3. Liu H, Qiao L, He Z (2012) Wernekink commissure syndrome: a rare midbrain syndrome. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 33 (6):1419-1421. doi:10.1007/s10072-012-0966-4 4. Mossuto-Agatiello L (2006) Caudal paramedian midbrain syndrome. Neurology 66 (11):1668-1671. doi:10.1212/01.wnl.0000218180.03127.11 5. Zhu Y, Liu HN, Zhang CD (2010) Wernekinck commissure syndrome is a pure midbrain infarction. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 17 (8):1091-1092. doi:10.1016/j.jocn.2009.11.032 Figure Legend Fig.1. Diffusion-weighted magnetic resonance image (MRI) showed diffusion restriction located in the paramedian midbrain (arrowheads).

Tay Sachs Is Fatal Health And Social Care Essay

By 2 years, Dj responded to auditor cues more than ocular 1s. He no longer could keep up his caput or perform simple activities such as turning the pages of a book.Nystagmus and a â€Å" cherry ruddy † was noticed by the paediatric eye doctor by so which would farther assist in his diagnosing. By this clip, he had regressed to a six months developmental degree ; his balance and vision were truly acquiring worse. At 2yrs, Dj was diagnosed with Tay Sachs by the brain doctor after his changeless visits and ratings. After this diagnosing a Deoxyribonucleic acid analysis for DJ was done to seek to happen the exact defect. A ruddy cell and leucocyte hex A degrees for his parents was done every bit good, to corroborate that both of them were bearers which was proven three hebdomads subsequently. The exact mutant in DJ could non be found which was non a surprise as more than 50 known mutants for this disease be but the research labs in the United States routinely trial for merely nine of the most common 1s. By two and a half old ages, his weight increased from 20 pounds at 2yrs to 25 lbs and he grew a few inches taller. At this pointing clip he had ictuss and experient minutes of agitating when being moved. Excess mucous secretion began constructing up in his pharynx which would subsequently after his lungs and external respiration. He was placed on Diamox for 6 months by so which aided him a spot with grow. His get downing physiological reactions weakened and congestion increased. He was besides placed on a tranquillizer which assisted in diminishing his shudders. By 3 year, he used a suction machine to take the extra mucous secretion so that he could be fed passed. His developments were being delayed further and he developed pneumonia as he became more susceptible to infections. As Dj turned four old ages, he no longer ate chiefly by oral cavity, but took repasts through a NG tubing. Although he did non take medicine to command his ictuss, he now took three medicines daily for other symptoms of the disease: A DiamoxA to cut down the force per unit area on his encephalon, A RobinulA to command extra secernments, andA ZantacA to command the sourness in his stomach.DJ was by no agencies lethargic or vegetive which is common for kids around that age enduring from the disease. He was alert for most of the twenty-four hours, and he moved himself around a batch, turned his ain caput and stretched his organic structure at will. He was really loose, and did non hold a job with contractures or palsy. By 5yrs, DJ received his repasts and medicines through his NG months.A He took three medicines daily for symptoms of the disease: A DiamoxA ( acetazolamide ) to cut down the force per unit area on his encephalon, A robinulA ( glycopyrrolate ) to command extra secernments, andA ativanA ( Ativan ) to assist him kip at dark. He retained some scope of motion eg.turning his ain caput, yawning and stretching his whole organic structure. His parents exercised his carpuss and pess more as they tended to drop down. Daily therapy was given to him by his parents which assisted in diminishing his ictus episodes and retaining some physical motion. Due to limited gesture he developed force per unit area sores as he invariably slept on one side of his organic structure. As small Dj approached his sixth birthday he started holding jobs such stiffness with contractures. It became really hard for him to make certain actions such as dividing his articulatio genuss or conveying his custodies away from his thorax as his shoulder blades would lift when his weaponries were lifted. He was still undergoing physical therapy in order to seek opening up his thorax to do it easier for him to take a breath. Gentle scope of gesture exercisings for his pess and custodies were done to loosen up the articulation in these countries. He experienced acidic belch as good which was discomforting for him. A few yearss before his birthday, Dj became one more statistic for Tay sachs. 1Today, most patients are seen in households with no anterior history of the disease because the recessionary cistron can be carried without being expressed through many coevalss. Carrier testing and familial guidance have made this disease rare in those at known hazard. While there are certain populations at higher hazard, A anyoneA can be a Tay-Sachs bearer.Pathogenesis and SymptomsTay sachs is a fatal autosomal recessionary familial upset in kids that causes the progressive devastation of the cardinal nervous system due to mutants in the HEXA cistron which encodes the alpha sub unit of the lysosomalA enzymeA beta-N-acetylhexosaminidase A. ( 3 ) In order to get the disease, both parents must be bearers of this mutauted HEX A which is to be inherited by an progeny. Possessing the 2 mutated HEX A is identified to be a 1 in 4 opportunity or 25 % .TheA HEXAA cistron provides instructions for doing portion of the enzyme beta-hexosaminidase A, which plays a of import portion in the encep halon and spinal cord. This enzyme is located in lysosomes which is why the disease is classified as a lysosomal storage disease or GM2 gangliosidosis. ( 2 ) Within the lysosomes, beta-hexosaminidase A helps interrupt down a fatty substance GM2 ganglioside. Mutants in theA HEXAA cistron disrupt the activity of beta-hexosaminidase A, which prevents the enzyme from interrupting down GM2 ganglioside. As a consequence, this substance accumulates to toxic degrees, peculiarly in nerve cells in the encephalon and spinal cord. Progressive harm caused by the buildup of GM2 ganglioside leads to the devastation of these nerve cells, which causes the marks and symptoms of Tay-Sachs disease.[ 2 ] Tay Sachs have been linked to about 90 mutants in the HEX A cistron with increasing Numberss. The type of mutants range from point mutants, omissions, splicing site mutants and many others. ( 1 ) Any of these mutants will merely increase the GM2 in the cells suppressing the map of the enzyme hexosaminidase.[ 3 ]A A four base brace interpolation inA exonA 11 ( 1278insTATC ) consequences in an alteredA reading frameA for the HEXA cistron. This mutant is the most prevailing mutant in the Ashkenazi Jewish population, and leads to the childish signifier of Tay-Sachs disease.[ 4 ]A mutant that is unrelated to the prevailing Ashkenazi mutant, a long sequence omission, occurs with similar frequence in households with Gallic Canadian lineage, and has the same pathological effects.This depicts that the fluctuations in the different mutants may hold similar symptoms. The different mutants may besides impact the type of Tay sachs which occurs. Three different types of Tay sachs has been identified ; childish, juvenile and grownup oncoming. Each is characterized by assorted mutants at different phases of the life rhythm. The assorted types and symptoms associated with them as are follows: Childish TSD: InfantsA withA Tay-Sachs diseaseA appear to develop usually for the first six months of life. Then, asA nerveA cells become distended with gangliosides, a grim impairment of mental and physical abilities occurs. The kid becomes blind, deaf, and unable to swallow.A MusclesA get down to atrophy andA paralysisA sets in. Death normally occurs before the age of five.[ 5 ] Late oncoming or Adult Onset ( LOTS ) ; seen in people between their 20s and 30s. This type is normally non-fatal and is seen due to diverse mutant forms. At first, the patient is heterozygous for the mutated cistron later developing two mutated HEXA cistrons that can demobilize, inhibit or change the actions of the hexosamamidase enzyme. This therefore illustrates that one time the patient has one transcript of the HEXAA geneA that still enables some hexosaminidase A activity, a ulterior onset signifier of the disease occurs. The symptoms typically are dysarthria, A proximalA ( bole ) A musculus failing, A tremorandA ataxy. Muscle spasms, particularly in the legs at dark, andA fasciculationsA ( musculus vellication ) are common. Not all symptoms are present in every person affected by the disease ; failing of the proximal musculuss, nevertheless, is a symptom common to all. Examples of trunk musculus failing may include trouble lifting from a sitting place, problem acquiring out of bed, fighting to equilibrate while acquiring dressed. Symptoms ofmanic-depressionA orA psychoticA episodes may be present in approximately 30 % of affected individuals.[ 6 ] Juvenile TSD ; mutants are similar to that found in the grownup onset type of TSD except that the disease occurs between the ages of 2 to 10 normally. This signifier of TSD is highly rare. They develop cognitive, motor, address, andA get downing troubles, ataxy and spasticity. These patients normally die between 5-15 old ages.DiagnosisDuring gestation, many antenatal trials can be used to name Tay-Sachs in the foetus before birth such as Amniocentesis and Chorionic Villus Sampling ( CVS ) .[ 7 ]Between the 10th and 12th hebdomads of gestation, an anticipant female parent can acquire a chorionic villus sampling, or CVS, in which a little sample of the placenta is drawn into a needle or a little tubing for analysis. A reddish topographic point in the dorsum of the oculus is displayed and is clearly seeable when viewed by an eye doctor or an oculist. In childish TSD patients, parents normally notice developmental holds but baby doctors frequently dismiss these concerns as normal slow developments. Around 10-14 months of age, TSD patients exhibit problem trailing or concentrating their eyes, which leads to an ophthalmologist visit. The reddish topographic point is rapidly seen and an initial diagnosing of Tay-Sachs or similar annihilating disease is made. Genetecist and brain doctor can normally name this disease every bit good due to the complications noted. Children with Juvenile Tay-Sachs or late oncoming TSD OR grownup TSD with chronic complications normally take a longer clip period to be diagnosed. . Many affected kids and grownups express assorted emotions when eventually acquiring a diagnosing. The enzyme check is a biochemical trial that measures the degree of enzyme in a individual ‘s blood. Babies, kids and grownups have low or non-existent degrees of Hex-A in their organic structure fluid and cells are diagnosed with Tay-Sachs. Low or non-existent degrees of Hex A enzyme will be noted in this disease.[ 8 ] An enzymatic trial can besides be done in order to look into the degree of enzymes in the blood. The public presentation of the HexA cistron can be checked in the serum and leucocytes.TreatmentTays Sachs has no remedy. The patients are merely treated in a mode which can help them in being comfy for the remainder of their lives. In add-on to this, household support can be given to assist the household members cope with the effects of this disease. Each of these intervention methods can be seen in our sample instance of small Dylan. Such methods are as follows ; 1 ) Medicines: used to forestall ictuss. Such medicines are tranquillizers, diamox ( for encephalon force per unit area alleviation ) , robinul ( extra secernment control e.g the extra mucous secretion ) 2 ) Respiratory attention: Tay-Sachs disease normally leads to an accretion of mucous secretion in the lungs. To cut down the sum of mucous secretion nowadays, thorax physical therapy ( CPT ) can be done. Parents of kids enduring from the disease are trained to transport out CPT. 9Children with Tay-Sachs disease are at high hazard of respiratory infections, which affect the lungs and cause external respiration jobs, and need to be carefully monitored and provided with prompt intervention. 3 ) Use of assistive devices: As seen in the instance of Dj, get downing physiological reactions weaken as the disease progresses doing it rather hard when feeding. Devicess can be used in order to feed the patients as the nutrient or fluid may come in the lungs doing sever respiratory jobs once more. The devices used are:[ 10 ]Nasogastric ( NG ) tubingthis is a tubing inserted through the olfactory organ to the tummy.Transdermal Esophago-Gastrostomy ( PEG ) tubingPEG tubings are placed through the venters into the tummy during a surgical process that is normally done by a physician specializing in gastroenterology or radiology. This option is more lasting than the NG tubing. 4 ) Physical Therapy:[ 11 ]Physical therapy for musculus and joint stimulation which increases flexibleness and scope of gesture. This is done by rub downing the affected organic structure parts. This helps detain joint stiffness or contractures cut downing or detaining the loss of map or the hurting that can ensue from contractures. hypertext transfer protocol: //www.djhomepage.com/ hypertext transfer protocol: //ghr.nlm.nih.gov/condition/tay-sachs-disease hypertext transfer protocol: //www.goldbamboo.com/topic-t2982-a1-6Tay-Sachs_Disease.html hypertext transfer protocol: //www.ntsad.org/ hypertext transfer protocol: //www.mayoclinic.org/tay-sachs-disease/treatment.html hypertext transfer protocol: //en.wikipedia.org/wiki/Tay % E2 % 80 % 93Sachs_disease hypertext transfer protocol: //kidshealth.org/parent/medical/genetic/tay_sachs.html # hypertext transfer protocol: //www.ntsad.org/S02/S02TS_diag.htm

Memorials

The Supreme Court may, in its discretion, grant special leave to appeal from any Judgment, decree, determination, sentence, or order in any cause or matter passed or made by any court or tribunal . Art 136 confers a discretionary power on the Supreme Court to interfere in suitable ceases, such as, a breach of natural Justice by the order appealed against or in exceptional ceases. The Supreme Court will intervene in if there has been a resultant failure of Justices or violation of principles of natural Justices or without a proper appreciation of material on record or the submissions made, interference under Art. 6 is warranted. The Supreme Court grant leave to appeal in criminal matters when exceptional and special circumstances exist, substantial and grave injustice has been done, and the case in question presents features of sufficient gravity to warrant a review of the decision appealed against or there has been a departure from legal procedure such as vitiates the whole trial, or if the findings of fact were such as were shocking to the judicial conscience of the Court.It would interfere where High Court's order results in gross miscarriage of Justice's. That special leave petition against interim order maintainable. The Supreme Court exercise its Jurisdiction under Art. 136 of the Constitution in respect of an interlocutory/interim order in especial circumstances to prevent manifest injustice or abuse of process of the Court 1 or where it is unsustainable on the face of it or where the interim order passed by the Division Bench of the High Court, on facts, is perverse in nature's or unreasonable.Where the interim order was not made in equity, interference by the Supreme Court was called forl.That the reasons for the decision must be given. A decision affecting the right of people without assigning any reason cannot be accepted as a procedure which is fair, Just and reasonable and hence violated of ‘reasons' may also be implied in the principles of â €˜natural Justice'17. Absence of reasoning is impermissible in Judicial pronouncement's.It is the reasoning alone, that can enable a higher or an appellate court to appreciate the controversy in issue in its correct perspective and to hold whether the reasoning recorded by the Court whose order is impugned, is sustainable in law and whether it has adopted the correct legal approach. To sub-serve the purpose of Justice delivery system, therefore, it is essential that the Courts should record reasons for its conclusions, whether disposing of the case at admission stage or after regular hearing proper reasoning is the foundation of a Just and fair decision.Failure to give reasons amounts to denial of Justice's. When the reason of a law once ceases, the law itself generally ceases. That order passed in violation of natural Justice is void. The breaches of rules of natural Justice must have the effect of producing void decisions. Any action in violation of principles of natural Justic e is a nullity and is altar-fires and hence suffers from Jurisdictional error. Thus, an order which infringes an fundamental freedom passed in violation of audit alters parted is a nullity.That decision of sub-ordinate court is in violation of Doctrine of Proportionality. The punishment imposed has to be reasonable because of the constraints of Art. 14. This means that if the punishment imposed is unreasonable, Art. 14 is infringed. The court can thus decide upon the proportionality of the punishment when it is strikingly disproportionate. The penalty imposed must be commensurate with the gravity of he misconduct, and that any penalty disproportionate to the gravity of the misconduct would be violated of Art. 14 of the Constitution.The freedom of speech is regarded as â€Å"a species of which freedom of expression is a genus†29 That a company can challenge the violation of its Fundamental Rights under Article 19 of the Constitution of India. The Supreme Court has stated that the law with regard to a company challenging the violation of its Fundamental Rights under Article 19 is in a â€Å"nebulous state†. The Court has gone on to say: â€Å"Thus apart from the law fundamental freedoms guaranteed by Art. 9, the rights of a shareholder and the company which the shareholders have formed are rather co-extensive and the denial to one of the fundamental freedom would be denial to the other.That intention is necessary for the offence of defamation under Section 499 of Indian Penal Code. In order to attract the offence of defamation under Section 499 of I. P. C. Mess area is required I. E. The publication must be made with intention to harm the reputation of a person against whom it was directed. The accused must have made the imputation with the intention of harming or with the knowledge that it will harm the reputation of the person defamed. Therefore, the intention to cause harm is the most essential â€Å"sine qua non† of an offence under Sec tion 49934.That a company cannot be held criminally liable for the offence of defamation. In view of Section 3(42), General Clauses Act, 1897 a company or association or body of individuals answers the definition of person. So, prima facie a company may be prosecuted for demotion. But, to invoke Section 499, the defamatory publication must be associated by delinquent's intention to cause harm. But company cannot be said to have the Mess area of forming an intention to cause harm because a company, a rustic entity cannot have any mind.If there is anything in the definition or context of a particular section in the statute which will prevent the application of the section to a limited company, certainly a limited company cannot be proceeded against. Then again a limited company cannot generally be tried when Mess area is essentially. The company is a legal entity which can be prosecuted if it is guilty of acts which make it punishable under the particular Criminal Statuette. So a comp any cannot be held to have committed an offence under Section 500, l. P. CO.That decision must be given after viewing publication as a whole. Publication must be Judged as a whole. The impact and effect of the imputations, if any, had to be considered in the background of the entire facts and circumstances stated therein. The bane and the antidote ought to have been considered together. If in one part of the publication there is something disreputable but it is removed by the other parts and the conclusions, then the disreputable part alone cannot be taken out in the process of picking and choosing in order to venture a prosecution for defamation.

Crimes of Killer Cop Antoinette Frank

Crimes of Killer Cop Antoinette Frank Antoinette Renee Frank (born April 30, 1971) is one of two women on death row in Louisiana.   On March 4, 1995, Frank was employed as a New Orleans police officer when she and accomplice Rogers Lacaze committed an armed robbery  at a restaurant and a killed New Orleans police officer and  two family members who were working at the restaurant. The motive of the murders was money. Frank interviewed with the New Orleans Police Department in January 1993. Despite that she was caught lying several times on her application and that after completing two psychiatric evaluations a firm do not hire status was recommended, the decision was made to hire her anyway. As a police officer cruising the streets of New Orleans, she came off as weak, indecisive and as some of her co-workers stated, borderline irrational. After her first six months on the force, her supervisor was close to having her return to the police academy for more training, but there was a shortage of manpower and she was needed on the streets. Instead, he teamed her up with a seasoned officer. Rogers Lacaze Roger Lacaze was a known 18-year-old  drug dealer who had been shot. Frank was the officer assigned to take his statement and a relationship between the two immediately transpired. Frank decided that she was going to help Lacaze turn his life around. However, the relationship quickly turned into a sexual one. Frank and Lacaze began spending a lot of time together and she did little to hide it from her fellow police officers or her superiors. She allowed him to ride in her police car when she was on duty and he sometimes accompanied her on calls. She would sometimes introduce him as a trainee or nephew. The Murders On March 4, 1995, Frank and Lacze showed up at the Kim Anh Vietnamese restaurant in east New Orleans, Louisiana, at 11 p.m. Frank had worked security at the restaurant and was on friendly terms with the family that owned and ran it. They would often give her food for free, even when she was not working. Fellow police officer Ronald Williams also worked security at the restaurant and was responsible for scheduling the other officers. He was there when Frank and Lacaze showed up.  Frank introduced Lacaze  as her nephew, but Williams recognized him as a thug who he had stopped on more than one occasion.   At around midnight, 24-year-old Chau Vu, who was working the restaurant with her sister and two brothers, decided it was slow enough to close. She was headed to the back to balance the money, when she noticed that the key to the restaurant was missing since the last time she had let Frank and her nephew out. She continued on to the kitchen to count money, then returned to the dining room to pay Williams who was working security that night.  Frank suddenly appeared back at the restaurant, shaking the door to come in. Sensing something was wrong, she went into the back and hid the money in the microwave, then returned to the front of the restaurant.   Earlier, after the first time the couple left, Williams told Chau Frank and her nephew were bad news. Chau had already decided that she did trust Frank after seeing her nephew, who looked like a gang member with his gold front teeth.   Chaus 18-year-old brother Quoc Vu, was talking with Williams when Frank returned. Chau shouted to him, not to let her in, but Frank came in on her own, using the missing key to open the door. As Frank walked into the restaurant, Williams approached her and confronted her about having a key, but she ignored him and continued towards the kitchen, shoving Chau and Quoc along with her. In the meantime, Lacaze, armed with a 9 mm pistol, came into the restaurant and shot Williams in the back of the head at close range, which immediately severed his spinal cord. Williams fell, paralyzed, and Lacaze shot him two more times in the head and back, killing him.He then took the officers revolver and his wallet. During the shooting, Franks attention turned to Lacaze, and Chau grabbed Quoc and an employee named Vui and they fled to the restaurants walk in- cooler, turned off the lights and hid. Chau, then Quoc carefully looked through the glass of the cooler to see what was going on. They watched as Frank and Lacaze searched frantically for the money. When they found it, they went to where Chaus older brother and sister were and forced them to their knees. The two siblings held hands and began praying and begging for their lives.   Frank shot both of them at close range with the same gun LaCaze had used to kill Williams. Then the killers began searching for the others. Assuming that they had escaped, Frank and Lacaze left the restaurant and drove away. Quoc ran to the neighbors to call 9.1.1. while  Chau stayed at the restaurant. She also called 911 but was so distraught after finding her brother and sister, and Williams dead, that she was unable to communicate clearly. Frank returned to the restaurant just seconds before the police. As Chau ran from the restaurant to a female police officer, it appeared that Frank was running after her, but she was stopped by the officers. She identified herself as a police officer and said that three masked men had escaped out the back door. Frank then approached Chau, and asked her what happened and if she was alright. Chau, in disbelief, and in broken English, asked why she would ask that, because she was there and knew what had happened. Sensing Chaus fear, the female officer pulled Chau away and told Frank not to leave. Slowly Chau was able to say what had happened. When Quoc returned to the scene, he validated what Chau had said. Frank was escorted to headquarters, after supplying the investigators with information on where she had dropped Lacaze off after leaving the restaurant after the shooting. When they were each interrogated, they pointed the finger at each other as being the trigger man. Frank finally said that she shot the younger brother and sister, but only because Lacaze had a gun to her head. They were both charged with armed robbery and murder. Death by Lethal Injection LaCaze trial was first. He tried to convince the jury that he was not at the restaurant and that Frank had acted alone. He was found guilty of three counts of first-degree murder and was sentenced to death by lethal injection. In October 1995 the jury sentenced Frank to death by lethal injection for the murders of Officer Ronald Williams and Ha and Cuong Vu. Update:  Rogers Lacaze is Granted a New Trial On July 23, 2015,  Ã‚  Judge Michael Kirby granted Rogers Lacaze a new trial because a former police officer was on the jury, which was in violation of jury rules. The juror,  Ã‚  David Settle, never revealed that he had worked for 20 years with the police.

The Association Against a Womans Right to Vote

The Association Against a Woman's Right to Vote At the end of the nineteenth century, Massachusetts was one of the most populous states and was from the beginning of the woman suffrage movement a center of activity for pro-suffrage activism.  In the 1880s, activists opposed to women voting organized, and formed the Massachusetts Association Opposed to the Further Extension of Suffrage to Women.  This was the beginning of the fight against a womans right to vote. From State Groups to a National Association The National Association Opposed to Woman Suffrage (NAOWS) evolved from many state anti-suffrage organizations.  In 1911, they met at a convention in New York and created this national organization to be active on both a state and federal level. Arthur (Josephine) Dodge was the first president and is often considered the founder.  (Dodge had formerly worked to establish day care centers for working mothers.) The organization was heavily funded by brewers and distillers (who assumed that if women got the vote, temperance laws would be passed). The organization was also supported by Southern politicians, nervous that African American women would also get the vote, and by big-city machine politicians. Both men and women belonged to and were active in the  National Association Opposed to Woman Suffrage. State chapters grew and expanded.  In Georgia, a state chapter was founded in 1895 and in three months had 10 branches and 2,000 members. Rebecca Latimer Felton was among those who spoke against suffrage in the state legislature, resulting in the defeat of a suffrage resolution by five to two.  In 1922, two years after the woman suffrage amendment to the Constitution was ratified, Rebecca Latimer Felton became the first woman Senator in the United States Congress, appointed briefly as a courtesy appointment. After the Nineteenth Amendment In 1918, the National Association Opposed to Woman Suffrage moved to Washington, DC, in order to focus on opposition to the national suffrage amendment. The organization disbanded after the Nineteenth Amendment, given women an equal right to vote, passed in 1920. Despite the victory for women, the NAOWS official newspaper,  Woman Patriot (formerly known as Womans Protest), continued into the 1920s, taking positions against womens rights. Various NAOWS Arguments Against Woman Sufferage Arguments used against the vote for women included: Women didnt want to vote.The public sphere was not the right place for women.Women voting wouldnt add anything of value since it would simply double the number of voters but not substantively change the outcome of elections - so adding women to the voting roles would waste time, energy and money, without result.Women didnt have time to vote or engage in politics.Women didnt have the mental aptitude to form informed political opinions.Women would be even more susceptible to pressure from emotional please.Women voting would overturn the proper power relationship between men and women.Women voting would corrupt women by their involvement in politics.States where women had already gained the vote had shown no increase in morality in politics.Women had an influence on the vote through raising their sons to vote.Women gaining the vote in the South would put more pressure on states to permit African American women to vote, and might lead to demolishing such rules as literacy tests, propert y qualifications, and poll taxes which kept most African American men from voting. Pamphlet Against Woman Suffrage An early pamphlet listed these reasons to oppose woman suffrage: BECAUSE 90% of the women either do not want it, or do not care.BECAUSE it means competition of women with men instead of co-operation.BECAUSE 80% of the women eligible to vote are married and can only double or annul their husbands votes.BECAUSE it can be of no benefit commensurate with the additional expense involved.BECAUSE in some States more voting women than voting men will place the Government under petticoat rule.BECAUSE it is unwise to risk the good we already have for the evil which may occur. The pamphlet also advised women on housekeeping tips and cleaning methods, and included the advice that  you do not need a ballot to clean out your sink spout and good cooking lessens alcoholic craving quicker than a vote. In a satirical response to these sentiments, Alice Duer Miller wrote Our Own Twelve Anti-suffragist Reasons (circa 1915).

Ethical Behavior Essay Example | Topics and Well Written Essays - 2000 words

Ethical Behavior - Essay Example All these factors work together in determining the ethical behavior of individuals and groups in organizations (Research(ICMR)). There is a great deal of controversy regarding the nature of ethical behavior. Even though some persons may consider their behavior ethical, their peers in the organization and people from other places of the world i.e. their counterparts may disagree. An employee may consider the use of office stationery like pens, envelops etc. for personal use as unethical, whereas his colleagues may feel that since these things are not very costly, using them for personal reasons is not wrong. The meaning of ethical behavior differs from individual to individual and from group to group. A research study in which business executives and business faculty members were asked to give their opinion on the unauthorized copying of microcomputer software revealed that while executives considered this behavior unethical, faculty members did not. Ethics, in philosophy, is the study and evaluation of human conduct in the light of moral principles. Moral principles may be viewed either as the standard of conduct that individuals have constructed for themselves or as the body of obligations and duties that a particular society requires of its members ((ICMR)). Ethics has developed as people have reflected on the intenti... Intuitionists, moral-sense theorists, and sentimentalists postulated an innate moral sense, which serves as the ground of ethical decision. Empiricists deny any such innate principle and consider conscience a power of discrimination acquired by experience. In the one case conscience is the originator of moral behavior, and in the other it is the result of moralizing. Between these extremes there have been many compromises. The Nature of the Good Another major difference in the approach to ethical problems revolves around the question of absolute good as opposed to relative good. Throughout the history of philosophy thinkers have sought an absolute criterion of ethics. Frequently moral codes have been based on religious absolutes. All varying methods of building an ethical system pose the question of the degree to which morality is authoritative (i.e., imposed by a power outside the individual). If the criterion of morality is the welfare of the state, the state is supreme arbiter (Arckatty). If the authority is a religion, then that religion is the ethical teacher. Professional Ethics What is Professional Ethics Professional Ethics concerns one's conduct of behavior and practice when carrying out professional work. Such work may include consulting, researching, teaching and writing (Research(ICMR)). The institutionalization of Codes of Conduct and Codes of Practice is common with many professional bodies for their members to observe. Any code may be considered to be a formalization of experience into a set of rules. A code is adopted by a community because its members accept the adherence to these rules, including the restrictions that apply. Good ethics and good business Why should a company consider ethics in directing